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Anti-CIP2A Polyclonal Antibody
產(chǎn)品簡介：

Anti-CIP2A Polyclonal Antibody
應(yīng)用 WB
稀釋比例WB 1:500-2000.
交叉反應(yīng)Human

產(chǎn)品型號：K106617P

更新時(shí)間：2022-08-15

廠商性質(zhì)：生產(chǎn)廠家

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產(chǎn)品介紹

Anti-CIP2A Polyclonal Antibody

英文名稱Anti-CIP2A Polyclonal Antibody
宿主Rabbit
別名CIP2A;KIAA1524;Protein CIP2A;p90
應(yīng)用WB
稀釋比例WB 1:500-2000.
交叉反應(yīng)Human
蛋白分子量102kd
Gene ID57650
保存Store at -20°C. Avoid freeze / thaw cycles.
儲存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原Recombinant protein of human CIP2A
性狀液體
Public Immunogen RangeRecombinant protein of human CIP2A
Subcellular LocationsCytoplasm Cell membrane
Swiss ProtQ8TCG1
克隆類型Polyclonal Antibody
背景資料Cancerous inhibitor of protein phosphatase 2A (CIP2A), also designated p90 autoantigen or KIAA1524, is a single-pass membrane protein that exhibits oncogenic activity. CIP2A is known to inhibit PP2A (protein phosphatase 2A) dephosphorylation of c-Myc, thereby stabilizing c-Myc (an oncogenic transcription factor) and promoting tumor formation and malignant cell growth. PP2A is a trimeric protein complex consisting of three subunits: a scaffold subunit, a catalytic subunit and a regulatory subunit. CIP2A specifically interacts with the catalytic subunit of PP2A to inhibit its activity. Inhibition of PP2A activity is a crucial step allowing for the progression of human cell transformation. Further supporting its role as an oncoprotein, CIP2A is known to be overexpressed in colon, gastric, and head and neck squamous cell carcinomas.

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